The “Calcium Paradox” and its Impact on Neurological and Psychiatric Diseases (Second Edition)
This book extends the original concept of the “calcium paradox” discovery, herein compiling more than 300 references in the field of calcium ion (Ca2+/cAMP) signalling pathways, neurotransmission and neurodegeneration, and neurological and psychiatric diseases. In this second edition, novel illustrations and tables (highlighting current medicines for treating these diseases, including their mechanism of action) offer improved insights into the concepts for students and clinicians. The description of other neurodegenerative diseases (Spinal muscular atrophy, Amyotrophic Lateral Sclerosis and Huntington´s disease) also adds further information with regards to treating these diseases. The growing increment in the life expectancy of the world's population has increased concern about age-related neurological diseases (neurodegenerative diseases), such as Alzheimer’s (AD) and Parkinson’s (PD) diseases, among others. It is now well-recognized that an imbalance of intracellular Ca2+ homeostasis contributes to the pathogenesis of neurological diseases like neurodegenerative diseases, including AD and PD, and others. Healthy brain aging can be promoted by regular exercise, moderation in caloric intake and engaging in intellectually challenging activities. These lifestyle factors may stabilize neuronal Ca2+ homeostasis. The discovery of the role of the “calcium paradox” due to the interaction between Ca2+ and cAMP signalling pathways (Ca2+/cAMP interaction) in neurotransmission, and neuroprotection, has subsidized the understanding of pathophysiology, and pharmacology, of the neurological and psychiatric diseases, opening a large pathway for the advancement of new pharmacological strategies for the treatment of these diseases. The proposal outlined in this book involves pharmaceuticals already approved, and may, in combination with improvements in lifestyle factors, allow sustained increments in the life quality of age-related neurological patients. Finally, this book briefly discusses other aspects of Ca2+/cAMP signalling pathways, such as their possible implications on cancer.
Dr Leandro Bueno Bergantin received his PhD from the Universidade Federal de São Paulo, Brazil, in 2014. His research involves cell signaling mediated by calcium ions, including its role in neuropsychopharmacology, autonomic and cardiovascular pharmacology, and cancer, and his studies have solved the enigma of the paradoxical effects produced by L-type calcium ion channel blockers. He has published over sixty articles in international journals, in addition to several book chapters, and is the author of a book. He is a member of the editorial boards of numerous international journals, and has participated in many international conferences.
Dr Afonso Caricati-Neto graduated in Biomedicine from Universidade Estadual Paulista, Brazil, in 1984, and received his MSc and PhD from Universidade Federal de São Paulo, Brazil, in 1989 and 1996. He has been Associate Professor at the Department of Pharmacology of Universidade Federal de São Paulo since 1989 and an Associate Researcher at Instituto Teófilo Hernando at Universidad Autónoma de Madrid since 2001. His research involves the pharmacology of drug receptors and intracellular signalling systems, and their role in physiological and pathological processes. He has published 150 scientific articles, 13 book chapters and one book on this subject.
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