Long Non-Coding RNA: From Disease Biomarkers to Targeted Therapeutics
Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are involved in diverse diseases like cancer, cardiovascular, autoimmune, hormonal disorders, neurodegeneration, and infection, among others. However, knowledge of the mechanisms by which they act is still ambiguous. As such, this book meets the essential need for a textbook dedicated to this topic and provides a comprehensive and captivating account of lncRNA research.
Syed Mudasir Ahmad, PhD, is an Associate Professor at the Division of Animal Biotechnology in the Faculty of Veterinary Sciences and Animal Husbandry at Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, India. He obtained his PhD from Jamia Millia Islamia, New Delhi, in 2006, and completed his postdoctoral fellowship at the University of California, Berkeley. He is the recipient of many prestigious national awards and international fellowships, and has published extensively. His work focuses on non-coding RNA expression in mammalian systems under diseased conditions and omics approaches to understanding disease resistance in animals.
Professor Nazir Ahmad Ganai is Director of Project Planning and Monitoring at Sher-e-Kashmir University of Agricultural Sciences and Technology, India. His work focuses on genomics and bioinformatics research, and he is the author of a number of books on these areas.
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